The Science & Treatment of Bipolar Disorder

<p>In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood.</p><p>For the full show notes, visit <a href="https://hubermanlab.com/the-science-and-treatment-of-bipolar-disorder/">hubermanlab.com</a>.</p><h2>Thank you to our sponsors</h2><p>AG1: <a href="https://athleticgreens.com/huberman">https://athleticgreens.com/huberman</a></p><p>LMNT: <a href="https://go.hubermanlab.com/lmnt-back-catalog">https://drinklmnt.com/hubermanlab</a></p><p>Waking Up: <a href="https://wakingup.com/huberman">https://wakingup.com/huberman</a></p><p>Momentous: <a href="https://livemomentous.com/huberman">https://livemomentous.com/huberman</a></p><h2>Timestamps</h2><p>(00:00:00) Bipolar Disorder</p><p>(00:03:42) Tool: Appetite Suppression &amp; GLP-1, Parallel Pathways, Yerba Mate</p><p>(00:9:19) Sponsors: AG1, LMNT</p><p>(00:14:24) Prevalence &amp; Severity of Bipolar Disorder</p><p>(00:16:30) Bipolar Disorder I, Diagnostic Criteria of Mania</p><p>(00:28:58) Bipolar Disorder II, Individual Variability</p><p>(00:33:07) Bipolar I vs. Bipolar II: Manic, Depressive &amp; Symptom-Free States</p><p>(00:38:20) Consequences of Bipolar Disorder, Heritability</p><p>(00:46:53) Bipolar Disorder vs. Borderline Personality Disorder</p><p>(00:51:51) Mania &amp; Depression, Negative Impacts</p><p>(00:53:06) History of Lithium Treatment</p><p>(01:02:44) Lithium Treatment &amp; Side-Effects</p><p>(01:05:05) Effects of Lithium: BDNF, Anti-inflammatory &amp; Neuroprotection</p><p>(01:10:10) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity</p><p>(01:17:11) Neural States &amp; Mania, Parietal Lobe &amp; Limbic System</p><p>(01:22:58) Homeostatic Plasticity, Synaptic Scaling, Lithium &amp; Ketamine</p><p>(01:36:00) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal &amp; Social Rhythm Therapy</p><p>(01:43:18) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS)</p><p>(01:48:01) Psylocibin, Cannabis</p><p>(01:51:50) Lifestyle Support, Supplements: Inositol &amp; Omega-3 Fatty Acids</p><p>(02:03:31) Omega-3s, Membrane Fluidity &amp; Neuroplasticity</p><p>(02:06:44) Mania, Creativity &amp; Occupations</p><p>(02:15:33) Bipolar Disorder: Diagnosis, Neural Circuits &amp; Treatment</p><p>(02:17:45) Zero-Cost Support, YouTube Feedback, Spotify &amp; Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter</p><p><a href="https://hubermanlab.com/disclaimer/">Disclaimer</a></p><p> </p><p>Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a></p>